Van Dijk was forced off just 11 minutes into the 2-2 Merseyside derby draw with Everton at Goodison Park after a heavy challenge from Jordan Pickford.
The Toffees goalkeeper’s rash scissor challenge trapped Van Dijk’s right knee and left him unable to continue, though he did walk off the pitch.
Pickford apologised for the incident post-match, revealed Liverpool captain Jordan Henderson after full-time.
Van Dijk was meanwhile sent for scans post-match with it speculated on Saturday evening in some quarters that the player has ruptured his anterior cruciate ligament.
That would leave Liverpool without their talismanic Dutch centre-half from anywhere between six to nine months, effectively ruling him out of the campaign.
Liverpool did not offer a public update but it is believed they are concerned they could be without Van Dijk for a significant period of time.
And This Is Anfield say that the Premier League champions are expected to offer more insight into the Netherlands international’s situation today once they themselves have been given a more thorough assessment of the problem.
The player has been sent to visit a specialist to better understand his condition, although the signs do not appear positive for the 29-year-old.
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Liverpool boss Jurgen Klopp said after the final whistle: “I don’t know. It’s not good.
“Virgil played I don’t know how many games in a row, he plays with pain, he plays with pretty much everything. But he couldn’t play on. That’s not good.”
Van Dijk has been an integral part of the Liverpool team that has won the Champions League and Premier League in the past two seasons.
And losing him for months at a time would be a major blow and would leave Liverpool relying on Joe Gomez and Joel Matip, both of whom have had injury troubles at Anfield.
Fabinho would serve as the third-choice centre-back with Nat Phillips and Billy Koumetio, just 17 years old, then the back-ups beyond that.
Liverpool were meanwhile left furious that Pickford was not punished for the challenge and have asked the Premier League to launch an investigation into how the Video Assistant Referee technology was applied.
They also had a stoppage-time Jordan Henderson goal that would have won them the match chalked off against the top-of-the-table Toffees for an incredibly marginal offside call.
The Athletic meanwhile say despite some claims that the VAR did review Pickford’s tackle on Van Dijk but somehow did not deem it worthy of a red card offence.
The fact the Liverpool defender was flagged offside by on-pitch officials meant a penalty could not be awarded but Pickford could still have been given his marching orders for serious foul play, they claim.
VAR official David Coote decided against punishing the England international shot-stopper however.
Liverpool are keen for the league to review the use of VAR on Pickford’s tackle and to disallow Henderson’s goal for an apparent Sadio Mane offside.
The Reds are also waiting to learn the extent of Thiago Alcantara’s injury with the Spanish midfielder, like Van Dijk, having been sent for scans.
Thiago complained of discomfort to Klopp after the match having been scythed down by a poor Richarlison tackle, for which the Everton attacker was sent off.